RESEARCH ARTICLE Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor,

Inflammatory pain is triggered by activation of pathways leading to the release of mediators such as bradykinin,prostaglandins, interleukins, ATP, growth factors and protons that sensitize peripheral nociceptors. The activation ofacid-sensitive ion channels (ASICs) may have particular relevance in the development and maintenance of inflammatory pain.ASIC3 is of particular interest due to its restricted tissue distribution in the nociceptive primary afferent fibres and its highsensitivity to protons.