A New Stereocontrolled Route to (+)-Curcuphenol, a Phenolic Sesquiterpene from the Marine Sponge Didiscus flavus.

Abstract Using a synthetic equivalent of chiral 2-cyclopentenol, (+)-curcuphenol, a cytotoxic bisabolane type sesquiterpene isolated from the marine sponge Didiscus flavus, has been synthesized through a concurrent retro-Diels–Alder reaction and Claisen rearrangement reaction.