Renal tubular transport and genetic hypotension

: The progressive improvement of genetic research technologies has led to the identification of different genes involved in blood pressure regulation. Renal regulation systems of sodium homeostasis play a key role. Mutations capable of determining an increase or a decrease in carrier proteins function could cause not only hypotension or hypertension, but also the related metabolic symptoms and changes, and the possible response to pharmacologic treatment. Monogenic forms of hyper- or hypotension are rare, though they highlight the importance of sodium tubular transport in blood pressure adjustment.