Relationship between serum fibroblast growth factor-23 level and vascular calcification in maintenance hemodialysis patients

Objective To investigate the relationship between serum fibroblast growth factor-23 level and vascular calcification in maintenance hemodialysis patients. Methods Ninty-two patients with maintenance hemodialysis in the Eighth Affiliated Hospital of Sun Yat-sen University from January 2017 to December 2017 were selected as the subjects. Chest X-ray was used to determine the degree of vascular calcification. Subsequently, the serum fibroblast growth factor-23 levels were measured by double antibody sandwich ABC-ELISA, and the relationship between vascular calcification score and fibroblast growth factor-23 level was analyzed by Spearman method. Results The incidences of moderate and severe vascular calcification in patients with age ≥60 years old, male and diabetes mellitus were higher than those in female patients with age <60 years old and non-diabetes mellitus. Compared with patients with calcification score<3 points in maintenance hemodialysis, the patients with calcification score (≥3 points) had higher daily dosage of calcium, so the levels of calcium-phosphorus product and serum albumin were also higher.The serum fibroblast growth factor-23 level of patients with calcification score (≥3 points)was significantly higher than that of patients with calcification score<3 points, and the serum fibroblast growth factor-23 level was positively correlated with serum phosphorus, calcium-phosphorus product and dosage of calcium. Conclusions Serum fibroblast growth factor-23 level is correlated with vascular calcification score. The higher the serum fibroblast growth factor-23 level, the more serious the vascular calcification will be. Clinically, serum fibroblast growth factor-23 level can be inhibited by regulating blood phosphorus content to improve the vascular calcification. Key words: Maintenance hemodialysis; Serum fibroblast growth factor-23 level; Vascular calcification