The clinical significance of dynamic changes of MCP-1 and IL-8 levels in patients with acute pancreatitis

Objective To evaluate the significance of detecting blood MCP-1 and IL-8 levels in evaluating the severity of the patients with acute pancreatitis(AP).Methods Serum concentrations of monocyte chemoattractant protein-1(MCP-1) and interleukin-8(IL-8) were detected dynamically by ELISA in 101 acute pancreatitis patients,including 78 mild AP(MAP) patients,13 severe AP without lung injury(SAPNLI) patients,10 AP with lung injury(APALI) patients,and 40 healthy volunteers(controls).Results(1) On the 1st day,the statistical difference was found in the serum concentration of MCP-1 between MAP cases and controls,SAPNLI cases and MAP cases,SAPNLI cases and APALI cases(P0.05).IL-8 in APALI cases was significantly different from that in SAPNLI cases(P0.01).(2) The levels of MCP-1 and IL-8 in MAP reached the peak level on the 3rd day after admission in all patients.(3)There was a significant statistical difference between SAPNLI cases and MAP cases,APALI cases and SAPNLI cases in the concentration of MCP-1 and IL-8 on the 3rd,7th,11th day after admission(P0.01).Conclusion Dynamic measurement of blood MCP-1 and IL-8 dynamically is useful in evaluating the severity of the patients with AP,and may be taken as a significant marker for predicting the lung injury in AP patients.