POEM correlates with EASI and other measures better than PO-SCORAD: A validation study.

BACKGROUND: Little is known about the measurement properties of Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD) in adults with AD. Even less is known about how PO-SCORAD performs compared to the Patient-Oriented Eczema Measure (POEM). OBJECTIVE: To examine the measurement properties of PO-SCORAD and compare them with POEM. METHODS: A prospective dermatology-practice based study of 291 AD patients (age 1872 years). RESULTS: PO-SCORAD and POEM were moderately correlated with each other (Spearman rho=0.56); had weak-moderate correlations with Numeric Rating Scale (NRS) worst-itch and average-itch, Dermatology Life Quality Index (DLQI), ItchyQOL, Patient-Reported Outcomes Measurement Information System (PROMIS) SleepDisturbance (SD) and Sleep-Related Impairment (SRI), Patient Health Questionnaire-9 (PHQ-9) and Eczema Area and Severity Index (EASI) (P<0.001). POEM had significantly stronger correlations with DLQI, ItchyQOL and EASI than did POSCORAD. PO-SCORAD and POEM had fair discriminant validity. Changes from baseline in PO-SCORAD and POEM were moderately correlated with each other, weakly to strongly correlated with NRS worst-itch and average-itch, DLQI, ItchyQOL, PROMIS SD, PROMIS SRI, PHQ9 and EASI and showed good test-retest reliability. There was no differential item functioning of items, or floor or ceiling effects for POSCORAD or POEM. The thresholds for meaningful change for PO-SCORAD and POEM were -15.5 and -5.0, respectively. Median completion time for PO-SCORAD and POEM was 3 and 1 minutes, respectively. CONCLUSION: PO-SCORAD and POEM showed good construct and cross-cultural validity, reliability, and responsiveness in adults with AD, and were feasible for use in clinical trials and practice. However, POEM showed better measurement properties than PO-SCORAD.