Acute hemodynamic, hormonal, and renal effects of neutral endopeptidase inhibition in ovine heart failure.
1992
The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days. Measurements were performed 1 h before and for 6 h after intraveous (i.v.) bolus administration of vehicle and SCH 39370 (1.25 and 5 mg/kg) on separate days
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