Non-coding RNA therapy in cancer

Abstract Complex diseases, such as advanced cancer, can rarely be treated with a single drug. Combinations of treatments are advised for the majority of types. Noncoding RNAs (ncRNAs), with their simultaneous activities and diversity of targets, often reaching several steps of a pathway, could be the right option to develop new treatment modalities. Because of their multifactorial effects, ncRNA-based therapeutics can also have a more stable effect in vivo than other forms of therapy. MicroRNAs (miRNAs) have already been targeted toward cancer and other diseases; however, the broad range of their effects often hinders successful clinical implementation. Extensive research is going on to fully understand the potential of ncRNAs. This can enable the development of effective and safe therapeutics for everyday oncological practice.