Expression of CD_(44s) mRNA in gastric carcinoma and its clinical significance

[Objective] To study the clinical significance of CD44s mRNA in gastric carcinoma (GO. [Methods] The expressions of CD44s mRNA in 66 cases of GC 25 cases of superficial gastritis and 25 cases of atypical hyperplasia were examined by in situ hybridization. [Results] There was no expression of CD44s mRNA in the group of superficial gastritis) the positive rate was 20% (5/25) in the group of atypical hyperplasia and 62. 12% (41/66) in the group of GC.The positive rate in poor differentiation group was obviously higher than that in well differentiation group (P0. 05), and positive lymph node metastasis group was higher than that in negative lymph node metastasis group obviously (P0. 05). [Conclusion] The expression of CD44s mRNA is related with the differentiation degree and lymph node metastasis, the activation of CD44s gene is related to strong invasion and poor prognosis of cancer cell.