Translational Medicine—a Paradigm Shift in Modern Drug Discovery and Development: The Role of Biomarkers

2010 
The analysis and utility of biomarkers along the process of drug discovery and development have become an integral part of the “learn and confirm” paradigm of drug discovery and development in leading pharmaceutical organizations. Such analyses are useful to guide the “learn phase” in search for biomarkers that can better assess the benefits and risks associated with manipulation of the molecular target. This article offers a utilitarian approach to biomarkers as well as target selection and validation that is driven by the translational medicine prospect of the target to become a successful drug target. Keywords: biomarkers; drug discovery; drug development; drug targets; translational medicine
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