Replacement renal therapy in complex treatment of severe acute pancreatitis

Abstract The purpose of this study was to retrospectively analyze the efficiency of replacement renal therapy (RRT) in multimodality treatment for severe acute pancreatitis (SAP) concurrent with a systemic inflammatory response and multiple organ failure/dysfunction. The authors analyzed the results of treating 55 patients (14 women and 41 men) aged 22 to 72 years (mean 43.5 +/- 16.4 years) treated at the intensive care units of Moscow City Clinical Hospital Fifty-Two in January 1, 2000, to December 31, 2006. All the patients had multiple organ dysfunctions with the involvement of 2 to 5 organs (median 4 (3; 4) and were on RRT. RRT may be successfully used in multimodality treatment for SAP provided that the dose of dialysis is at least 35 ml/kg/hour. The severe condition rated by the APACHE HII and SAPS II scales and the dialysis dose of less than 35 ml/kg/hour are independent risk factors of death in SAP patients.