Preparation of cyclic peptide libraries using intramolecular oxime formation.
2004
A new method for the synthesis of cyclic head-to-side chain peptide libraries has been developed in which the key cyclization step involves reaction between a C-terminal ketone and an N-terminal hydroxylamine to form a macrocyclic oxime. This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers. Copyright © 2004 European Peptide Society and John Wiley & Sons, Ltd.
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