Zinc inhibition of group I mGluR-mediated calcium homeostasis in auditory neurons.

calyces. The presence of zinc inhibits mGluR5, a major component of calcium homeostasis of NM neurons, and plays a modulatory role in the activity-dependent, Zinc is widely distributed in the central nervous system (CNS), it functions normally as a synaptic modulator, mGluR-mediated calcium homeostasis of auditory neurons. and it contributes to neuronal death under pathologic conditions. Zinc colocalizes with glutamate in excit- Keywords: chick nucleus magnocellularis, metabotropic glutamate receptor atory synapses, and the presence of zinc is well characterized in the synapses of the auditory system. Since chick cochlear nucleus neurons depend upon synaptic activation of metabotropic glutamate receptors (mGluRs) for maintenance and survival, the goal of this study was to determine (1) if zinc is released from the eighth nerve calyces onto nucleus magnocellularis INTRODUCTION