Disposition kinetics of ceftizoxime in acute mastitis in Murrah buffaloes

Acute mastitis was induced by inoculation of Staphylococcus aureus in 6 buffaloes. Ceftizoxime was administrated intravenously @25 mg/kg to evaluate pharmacokinetics of ceftizoxime in mastitic buffaloes. The maximum mean plasma concentration of ceftizoxime was recorded at 0.08 h in healthy buffaloes which was followed by decreased plasma concentration of 23.53 ± 0.84 μg/ml at 1 h and persisted up to 24 h. Mean values of t½s were 5.86 ± 0.18 and 8.42 ± 0.58 h in healthy and induced mastitic buffaloes, respectively. Mean Vdarea value of 1.10 ± 0.06 L/kg in healthy buffaloes was increased significantly. The maximum mean milk concentration of ceftizoxime at 2 h (73.34 ± 4.35 μg/ml) in lactating buffaloes decreased gradually till 12 h (31.31 ± 5.66 μg/ml) and persisted up to 96 h (1.57 ± 0.20 μg/ml). So, ceftizoxime can be used for treatment of staphylococcal mastitis in buffaloes.