A new target spot for the treatment of postoperative cognitive dysfunction:the GABA_A receptor related-drugs
2013
Background Postoperative cognitive dysfunction (POCD) is one of the most common perioperative complications. The γ-aminobutyricacid type A (GABAA) receptor, which is a type of inhibitory receptor in central nervous system, may play an important role on the development of POCD. Objective To review the effects of GABAA receptor related-drugs on POCD. Content GABAA receptor agonist, GABAA receptor antagonist and GABA_A receptor inverse agonist, may have effects of induction, inversion or improvement on POCD, respectively. Trend The GABAA receptor related -drugs may provide a new attractive therapeutic option for POCD, and it maybe a highlight of future research.
Key words:
Postoperative cognitive dysfunction; γ-aminobutyricacid type A receptor; γ-aminobutyricacid type Areceptor antagonist; γ-aminobutyricacid type A receptor agonist
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI