2013 Electrocardiographic estimate of ischemic acuteness is superior to time from pain onset for predicting myocardial salvage as assessed by SPECT and MRI in patients undergoing primary percutaneous coronary intervention

Introduction Based on animal studies, it is currently accepted that duration of ischemia is a major determinant of the ability to salvage jeopardized myocardium by restoring the coronary blood flow and myocardial perfusion. In experimental animal studies it is possible to determine the exact time of occlusion as well as to ensure complete, persistent ischemia during the time of coronary occlusion. In humans, however, it is impossible to determine either the exact time of acute occlusion or whether spontaneous reperfusion and re-occlusion has occurred prior to the time of reperfusion therapy.