[Preparation of colon target pellets of Pulsatilla total saponins-hydroxypropyl-beta-cyclodextrin inclusion].

Objective: To prepare colon target pellets of Pulsatilla total saponins. Method: Pulsatilla total saponinshydroxypropyl-β-cyclodextrin inclusion was prepared by the water solution-mixing method. Then plain pills of inclusion were prepared by the granulation-spheronization method,and coated by Glatt fluid bed. Result: The dissolution of plain pills of Pulsatilla total saponins at 2 h was 16. 0%,while that of plain pills of inclusion at 0. 5 h was 91. 9%. With Eudragit S100 as the coating material,TEC as the plasticizer and talcum power as the anti-adherent,when the coating weight was 12%,the coating efficiency was high,with almost no bonding and drug release of coated pellets in artificial gastric juice for 2 h. The accumulated drug release in artificial intestinal fluid for 4 h was less than 15%,and that in artificial colon fluid for 4 h was more than 90%. Conclusion: Coated pellets of Pulsatilla total saponins-hydroxypropyl-β-cyclodextrin inclusion showed a good colon targeted drug release in vitro,thus could be further developed to be oral colon targeted preparations.