m 1 A and m 1 G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs

Huiqing Zhou,Isaac J. Kimsey,Evgenia N. Nikolova,Bharathwaj Sathyamoorthy,Gianmarc Grazioli,James McSally,Tianyu Bai,Christoph H. Wunderlich,Christoph Kreutz,Ioan Andricioaei,Hashim M. Al-Hashimi

m 1 A and m 1 G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs

2016

Huiqing Zhou
Isaac J. Kimsey
Evgenia N. Nikolova
Bharathwaj Sathyamoorthy
Gianmarc Grazioli
James McSally
Tianyu Bai
Christoph H. Wunderlich
Christoph Kreutz
Ioan Andricioaei
Hashim M. Al-Hashimi

The inability of A-form RNA to form Hoogsteen base pairs provides a mechanism for how post-transcriptional modifications can disrupt RNA structure and might help explain why DNA is the molecular choice for storing genetic information.

Keywords:

Guanosine
Instability
RNA Stability
RNA
Nucleic acid structure
DNA
Biochemistry
Inverted Repeat Sequences
Stereochemistry
Base pair
Chemistry
Duplex (building)
Helix

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