Myocardial 82 RB Kinetics Identify Cell Membrane Integrity and Tissue Viability
1996
The clinical application of radionuclides in the assessment of residual tissue viability after myocardial infarction or prolonged ischemia is based on the ability of several radioisotopes to delineate cell function, particularly of cell membrane integrity or cellular substrate metabolism. The rationale for their use is based on the experimentally proven fact that only viable cells with intact sarcolemmal membranes can retain the tracers. In contrast, accelerated tracer leakage or inability to trap the radionuclides inside the cell suggests the presence of irreversible cell damage. It is now widely accepted that tracers of cell membrane integrity or cellular metabolism provide accurate noninvasive detection of preserved tissue viability of dysfunctional myocardium in patients with advanced coronary artery disease [1].
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