Survival status of patients with esophageal squamous cell carcinoma in Yangzhong City and the prognostic significance of protein expressions of XRCC1 and MGMT

Objective: To investigate the survival status of esophageal squamous cell carcinoma (ESCC) patients and explore the impact of protein expressions of X-ray repair cross-complementing gene 1 (XRCC1) and O6-methylguanine-DNA methyltransferase (MGMT) on the prognosis of ESCC as well as their potential relationships with clinicopathological indices in Yangzhong City, Jiangsu Province. Methods: The data on 432 patients with ESCC between 2004 to 2008 were obtained from Yangzhong Cancer Registry System. The protein expressions of XRCC1 and MGMT in ESCC tissues were assessed by immunohistochemistry. Totally, 405 patients (94%) were followed-up. Correlations between two protein expressions and clinicopathological parameters were analyzed by Spearman correlation coefficient. Survival rates were estimated by Kaplan-Meier method. Single prognostic factors were analyzed by Log-rank test. COX regression model was used to perform multivariate analysis and hazard ratio (HR) calculation. Results: The total one-, three-, five-year survival rates of ESCC patients were 85.7%, 60.6% and 51.4% in Yangzhong City, respectively. ESCC survival was associated with T stage (degree of tumor invasion) and N stage (lymph node metastasis) (P 0.05). There was a statistically significant negative relationship between the protein expression of MGMT and pathologic stage (r = -0.303, P = 0.002). Conclusion: The overall survival status of ESCC is improved in Yangzhong City. The protein expressions of XRCC1 and MGMT may have no significant effects on prognosis of ESCC patients. DOI:10.3781/j.issn.1000-7431.2013.12.010