Hierarchical Structure of Bone and Micro-Computed Tomography

More than 130 years have passed since early investigators described the coincident relationship between the orientation of trabecular bone and the presumed direction of principal stresses engendered during habitual activity.1-4Stimulated by these early perceptions, current investigators continue to explore structure function relationships for bone as a means to understand the basis for its resistance to failure or its strategy for adapting to functional demands while remaining a participant in mineral homeostasis.