Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine

José Neves,Johan Michiels,Kevin K. Ariën,Guido Vanham,Mansoor Amiji,Maria Fernanda Bahia,Bruno Sarmento

Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine

2012

José Neves
Johan Michiels
Kevin K. Ariën
Guido Vanham
Mansoor Amiji
Maria Fernanda Bahia
Bruno Sarmento

Purpose To assess the intracellular delivery, antiretroviral activity and cytotoxicity of poly(e-caprolactone) (PCL) nanoparticles containing the antiretroviral drug dapivirine.

Keywords:

Microbicides for sexually transmitted diseases
Drug
Nanoparticle
Drug development
Dapivirine
Pharmacology
Intracellular
Cytotoxicity
Microbicide
Chemistry
polymeric nanoparticles
drug candidate

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