Solid-Phase Synthesis of 4,5-Disubstituted-1,2,4-triazole-3-thione Derivatives Based on the Resin-Bound Acylhydrazines

Abstract Highly efficient solid-phase synthesis of 4,5-disubstituted-1,2,4-triazole-3-thiones under mild conditions has been developed. 4,5-Disubstituted-1,2,4-triazole-3-thione derivatives were synthesized from resin-bound acylhydrazines in several steps, providing 76–89% overall yields and excellent purity.