Effect of sodium butyrate on expression of VEGF in HT-29 colon carcinoma cell

Objective To detect the effects of sodium butyrate on the growth of HT-29 colon carcinoma cells and the expression of vascular endothelial growth factor(VEGF).Methods MTT assay, light microscopy and immunocytochemistry were used to observe the growth and expression of VEGF in HT-29 cell line after treated by sodium butyrate.Results Sodium butyrate inhibited the growth of HT-29 cell lines and decreased the expression of VEGF in HT-29 cell line.Conclusion Sodium butyrate could inhibit the expression of VEGF. It may play an important role in decreasing the tumor angiogenesis.