Response to Comment on “CD226 Is Specifically Expressed on the Surface of Th1 Cells and Regulates Their Expansion and Effector Functions”

We recently described that CD226 is specifically expressed on differentiated Th1 T cells ([1][1]). Using a novel rat 10E5 mAb, we find that ∼40% of CD4+T cells purified from the spleen of C57BL/6 express CD226. Upon activation, CD226 is up-regulated on all CD4+ T cells, independent of their Th