Short Intrinsically Disordered Polypeptide-oligonucleotide Conjugates for Programmed Self-assembly of Nanospheres with Temperature-dependent Size Controllability

A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.