Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin

CCT/TRiC is a eukaryotic multi-subunit chaperonin that promotes the correct folding of many cytosolic proteins, including tubulin, within its cavity. Now the crystal structure of CCT in its open state is solved to 5.5-A resolution and, together with EM and biochemical analysis, allows the observation of a bound tubulin molecule interacting with CCT loops in the apical and equatorial domains.