Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis

Veronica Di Paolo,Chiara Fulci,Dante Rotili,Francesca Sciarretta,Alessia Lucidi,Blasco Morozzo della Rocca,Anastasia De Luca,Antonio Rosato,Luigi Quintieri,A.M. Caccuri

Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis

2019

Veronica Di Paolo
Chiara Fulci
Dante Rotili
Francesca Sciarretta
Alessia Lucidi
Blasco Morozzo della Rocca
Anastasia De Luca
Antonio Rosato
Luigi Quintieri
A.M. Caccuri

The antitumor agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (1) is a potent inhibitor of GSTP1-1, a glutathione S-transferase capable of inhibiting apoptosis by binding to ...

Keywords:

Organic chemistry
Hydrolysis
Benzamide
Chemistry
Apoptosis
antitumor activity
Glutathione
Combinatorial chemistry
Thio-
GSTP1

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