In Vitro Antioxidant Activity of 1-(5-(4-Methoxy-phenyl)- (1,3,4)oxadiazol-2-yl)-piperazine Derivatives

A series of new 1-(5-(4-methoxy-phenyl)-(1,3,4)oxadiazol-2-yl)-piperazine derivatives 2(a-g) were screened for their antioxidant activity by 2,2-diphenyl-1-picryl-hydrazyl (DPPH • ), hydroxyl radical (OH • ) and nitric oxide radical (NO • ) methods. Butylated Hydroxytoluene (BHT) was used as standard. All the compounds showed activity, where compound 2c was the best radical scavenger. These findings show that the 2,5-disubstituted-1,3,4-oxadiazole possesses antioxidant activity with different mechanism of actions towards the different free radicals tested.