Encapsulation of trans-resveratrol in poly(ε-caprolactone) by GAS antisolvent

Abstract In this study, poly(e-caprolactone) particles containing resveratrol were developed employing the GAS antisolvent technique. A central composite design 22 evaluated the influence of polymer, resveratrol mass ratio (2:1, 1:1, 1:2), and pressure (100, 120, 140 bar) on encapsulation percentage, and efficiency. The values obtained for encapsulation efficiency and percentage of encapsulation at the best conditions attained were 99.34% and 65.31%. In addition, the statistical analysis showed that only the mass ratio had significantly affected the percentage of encapsulation, but neither variable significantly affected efficiency. Microparticles produced demonstrably heterogeneous characteristics and irregular morphology. However, this process did not change either the compound chemical structures or the resveratrol antioxidant activity. Microparticles maintained constant release for 48 h, and in thermal oxidative analysis, the difference between samples and control was 2.57 times smaller than the difference between pure resveratrol and the control sample.