Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study

The stronger sulfonamide–pyridine (SO2NH2⋯N-Py) and sulfonamide–carboxamide (SO2NH2⋯OC–NH) hydrogen bonds direct the formation of cocrystals, while the weaker sulfonamide–amine (SO2NH2⋯N–H) hydrogen bond results in coamorphous products. IDP–PIP and IDP–ARG coamorphous solids exhibit remarkable stability under accelerated conditions.