Response by Liu to Letter Regarding Article, “Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis”

We want to thank Jin-shan and Xue-bin for bringing up important questions regarding the clinical perspective of tumor necrosis factor receptor-associated factor 2 (TRAF2) signaling in the heart. First, our study identified TRAF2 as a critical prosurvival factor by suppressing apoptosis and necroptosis in cardiomyocytes;1 both forms of programmed cell death are critically involved in the pathogenesis of myocardial infarction and chronic heart failure.2 We showed that ablation of TRAF2 predisposed the heart to pathological remodeling and heart failure by promoting death receptor (eg, TNFR1)-mediated apoptosis and necroptosis signaling.1 Tumor necrosis …