Imaging Sympathetic Innervation of the Heart: Therapeutic Strategies SPECT/CT and PET/CT

Tracers for radionuclide imaging of cardiac neurotransmission have been developed by radiolabeling true neurotransmitters or corresponding structural analogs (false neurotransmitters). The most commonly used radiopharmaceuticals to assess cardiac neurotransmission are [11C]-metahydroxyephedrine ([11C]-mHED), [11C]-ephedrine, [18F]-dopamine, and [123I]-metaiodobenzylguanidine ([123I]-MIBG), which estimate neuronal presynaptic reuptake (type I uptake) and storage of norepinephrine (NE).