Imaging Sympathetic Innervation of the Heart: Therapeutic Strategies SPECT/CT and PET/CT
2015
Tracers for radionuclide imaging of cardiac neurotransmission have been developed by radiolabeling true neurotransmitters or corresponding structural analogs (false neurotransmitters). The most commonly used radiopharmaceuticals to assess cardiac neurotransmission are [11C]-metahydroxyephedrine ([11C]-mHED), [11C]-ephedrine, [18F]-dopamine, and [123I]-metaiodobenzylguanidine ([123I]-MIBG), which estimate neuronal presynaptic reuptake (type I uptake) and storage of norepinephrine (NE).
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