361. A Case Control Study of COVID-19 Outcome in Patients with HIV

Background: Little is known regarding outcome of patients living with HIV (PLWH) when they get admitted to a hospital for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection We decided to conduct a case-controlled study to try to answer the question if PLWH are at higher risk of mortality compared to individuals without HIV infection but with the same risk factors that affects outcome in COVID-19 disease Methods: A retrospective case matched control study was performed from 03/15/2020 to 05/15/2020 We reviewed all confirmed SARS-CoV-2 infected patients who were admitted to our hospital during the study period and retrieved 7 variables: Age, gender, diabetes mellitus (DM), hypertension (HTN), body mass index (BMI), chronic kidney disease (CKD), HIV status We divided the age in 3 groups ( 60), we defined the presence of DM and HTN by reviewing the admission medications, BMI > 30 defined obesity, and CKD was present if eGFR 60 years old Male to female ratio was 1:1 (6 patients each) Comorbidities were present in 10 patients (83%) with HTN (83%) being the most common, followed by CKD (58%), obesity (33%), and DM (33%) Only 1 patient expired out of the 12 PLWH (8%) admitted with COVID-19, as compared to 26 patients from the 98 matched cohort (27%) (z-score 1 38, p=0 17;odds ratio [OR], 3 972;95% confidence interval [CI], 0 62-44 37) Conclusion: Our study suggests that PLWH do not have a worse prognosis than their matched controls for the most significant comorbid conditions affecting outcome in COVID-19 disease Further studies with a larger sample size are urgently needed to confirm this finding