The Micronucleus Test of Meddroxyprogesterone Acetate in Bone Marroww Polychromatic Erythrocytes and Spermatogenic Cells of Malerats

BACKGROUNDAIM: To study the effect of Meddroxyprogesterone Acetate on the micronucleus rate in bone marrowpolychromatic erythrocytes and spermatogenic cells of male rats. MATERIAL AND METHODS: 50rats were classified into4groups.Each group received injection of saline(groupC)or MPA(37.5,75and150mg/kg)(group P 1 ,group P 2 and group P 3 ,respectively)for every month during3months.Data from sperm counting,sperm modality,and the micronucleus rate in bone marrow polychromatic erythrocytes and spermatogenic cells were collected and analysed. RESULTS: Spermatogenesis of rats undergoing administration of MPA had been suppressed.Testis of rats in group P 1 ,P 2 and P 3 atrophied and sperm counting decreased remarkably compared with group C.There was no statistics difference of the micronucleus rate in bone marrow polychromatic erythrocytes between each group.The micronucleus rate in spermatogenic cells in group P 2 and P 3 raised,but resumed to normal after MPA deprived9months. CONCLUSION: MPA has no significant effecton increasing the incidence of the micronucleus rate in bone marrow polychromatic erythrocytes,while it can reversibly raise the micronucleus rate in spermatogenic cells.