Sustainable release of nanodrugs: A new biosafe approach

Abstract Recently, there have been enormous developments in the field of drug delivery systems to provide therapeutic agents to its target location for the treatment of various ailments. Nanomaterials-based drug delivery systems are currently successfully developed which can facilitate the advanced system of drug delivery. Drugs with very low solubility possess various biopharmaceutical delivery issues including limited bioaccessibility after intake through mouth, less diffusion capacity into the outer membrane, require more quantity for intravenous intake and unwanted aftereffects preceding traditional formulated vaccination process. However, all these limitations could be overcome by the application of nanotechnology approaches in the drug delivery mechanism. Drug designing at the nanoscale is one of the most promising areas in drug delivery because of its potential advantages such as the possibility to modify properties like solubility, drug release profiles, diffusivity, bioavailability, and immunogenicity. This can consequently lead to the improvement and development of convenient administration routes, lower toxicity, fewer side effects, improved bio-distribution, and extended drug life cycle. In this chapter, we discuss the prospect of different nanoparticles as drug or drug carriers for sustainable and targeted drug release.