Breast cancer recurrence in older patients with clinically node-negative T1-T2 tumors managed without sentinel node biopsy (SNB) and without adjuvant radiation therapy.

528 Background: Older patients (pts) with small breast cancers who receive endocrine therapy can omit radiation without a survival disadvantage. SNB adds additional burden and may not be necessary for pts who are not planning adjuvant radiation or chemotherapy. The objective of our study was to evaluate recurrence rate with or without SNB in those pts. Methods: We retrospectively reviewed records of pts ≥ 60 years (y) old, diagnosed at our center between 2000 and 2014 with T1-T2, clinically node-negative, estrogen receptor-positive breast cancer, who did not receive adjuvant radiation or chemotherapy. We used Fisher’s exact test to compare characteristics, and Gray’s test for cumulative incidence function (CIF) for cancer recurrence, with 95% confidence intervals. Results: We identified 364 pts. Those managed without SNB were significantly older, more often with apocrine, mucinous or papillary histology and less likely to undergo mastectomy, with no significant differences in other characteristics. There ...