As heteroaryl-substituted pyrrole Janus kinase inhibitors and [2,3-b] pyridine and pyrrolo [2,3-b] pyrimidine

The present invention provides heteroaryl substituted pyrrolo [2,3-b] pyridin-aryl and heteroaryl substituted pyrrolo [2,3-b] pyrimidine, which regulates the activity of Janus kinases and for the treatment of Janus kinase activity-related diseases, including, for example, immune - related diseases, skin diseases, myeloproliferative disorders, cancer and other diseases.