New Approach to 3-Aminothiophene-2-carboxylic Acid Derivatives: Access to 5-Aryl-4-(ethylsulfanyl) Compounds.

Abstract Treatment of DMSO/water solutions of β‐bromo‐α‐(ethylsulfanyl)cinnamonitriles with sodium sulphide and α‐halo acetic acids derivatives followed by cyclization in a potassium carbonate/acetone/DMSO mixture gave the expected 3‐amino‐5‐aryl‐4‐(ethylsulfanyl)thiophene‐2‐carboxylic acids derivatives in fair yields.