Kallikrein-related peptidase 4 induces tumour microenvironment alterations that support tumour growth
2015
Kallikrein-related peptidase 4
(KLK4) is a protease with elevated production
in prostate cancer versus benign tissue.
KLK4 expression is associated with
prostate cancer risk, and its activity
favours tumour progression through
increasing cell motility and growth.
Importantly, over-production of KLK4 in
prostate glandular cells precedes tumour
formation, positioning the enzyme to play
a role in early remodelling of the tumour
microenvironment, a process essential for
tumour growth. We sought to identify the
proteins and downstream signalling pathways
targeted by KLK4 activity, to define
its role in tumour microenvironment
remodelling and evaluate the efficacy of
KLK4 inhibition as a cancer therapy.
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