5,6,7,8-tetrahydropyrido[3,4-d] pyrimidine compound with bioactivity as well as preparation method and application thereof

The invention discloses a 5,6,7,8-tetrahydropyrido[3,4-d] pyrimidine compound with a bioactivity as well as a preparation method and an application thereof, and belongs to the technical field of synthesis for a compound with an anti-tumour activity. The essential of the technical scheme of the invention is as follows: the 5,6,7,8-tetrahydropyrido[3,4-d] pyrimidine compound with the bioactivity has a structure specified in the description, wherein R1 is ethyl formate, ethylamine methyl group, methylamine formyl group, dimethylamino formyl group, pyridine-3-formamidino formyl group, pyridine formyl group or anilino formyl group, and R2 is hydrogen or benzyl group. The invention further discloses a preparation method for the 5,6,7,8-tetrahydropyrido[3,4-d] pyrimidine compound with the bioactivity and an application thereof in preparation for an anti-breast tumour medicine. The preparation process disclosed by the invention is simple in process, easy to control, high in target product yield and good in repeatability; the prepared 5,6,7,8-tetrahydropyrido[3,4-d] pyrimidine compound with the anti-tumour activity has an inhibition effect on breast cancer cells MCF-7 to a certain extent.