Recovery of posterior communicating artery aneurysm-induced oculomotor nerve paresis after endovascular treatment and its related factors analysis

Objective To investigate the evolution of posterior communicating artery (PcomA) aneurysm-induced oculomotor nerve paresis (ONP) and the factors affecting the outcome of ONP after endovascular packing of PcomA. Methods A total of 55 patients with ONP attributable to PcomA, admitted to our hospital from July 2007 to January 2013, were chosen in our study; their clinical data were retrospectively analyzed. The recoveries of ONP were analyzed;univariate analysis and multivariate Logistic regression were used to explore the possible influencing factors of recovery. Results At least one year follow up showed that there was a complete resolution of ONP in 31 patients (56.4%), partial improvement in 19 (34.5%) and no changes in 5 (9.1%). Multivariate Logistic regression analysis indicated that preoperative degrees of paralysis (OR=5.366, 95%CI: 1.253-22.974, P=0.024), preoperative paralysis time (OR=5.518, 95% CI: 1.398-21.774, P=0.015) and mecobalamine treatment (OR=6.988, 95%CI: 1.659-29.431, P=0.008) were significantly associated with the recoveries of oculomotor nerve function after endovascular treatment. Conclusion Endovascular treatment can promote the recovery of PcomAaneurysm-induced ONP, and preoperative degrees of paralysis, preoperative paralysis time and mecobalamine treatment are factors influencing the complete recovery of ONP. Key words: Intracranial aneurysm; Oculomotor nerve paresis; Embolization; Recovery; Related factor