Toxic Hazards Research Unit Annual Technical Report: 1985

Abstract : The research program of the Toxic Hazards Research Unit (THRU) for the period of June 1984 through May 1985 is reviewed in this report. Chronic toxicity and oncogenic studies were carried out with hydrazine, JP-4, and JP-8. Results of histopathologic examination became available for a number of studies including chronic inhalation exposures to monomethylhydrazine, methylcyclohexane, and Otto Fuel II; and subchronic to petroleum and oil shale diesel fuel marine. These studies are now complete. Other investigations are complete except for histopathologic results. These include chronic exposures to petroleum JP-4, RJ-5, JP-7, JP-TS, and JP-10; subchronic exposures to petroleum JP-4 and JP-8; and weekly exposures to hydrazine. Three studies have concluded the exposure phases and are now being held postexposure - 90 day continuous exposures to shale JP-4 and dimethyl methylphosphonate and rat strain susceptibility to shale JP-4. A series of short-term toxicity studies was conducted on a variety of chemicals and chemical agents used by the Army, Air Force, and Navy.