Abstract 14134: Factors that Contribute to Tissue Characteristics of Coronary Plaques Differ Depending on Renal Function in Type 2 Diabetes Mellitus

Introduction: Glycemic variability plays an important role in the coronary plaque formation mainly via inflammatory pathways in patients with type 2 diabetes mellitus (T2DM), but the pathogenesis of diabetic kidney disease is also closely linked to chronic inflammatory processes and subsequent progression of coronary atheromatous plaques. Hypothesis: We hypothesized that factors that contribute to tissue characteristics of coronary plaques differ depending on renal function in T2DM. Methods: We prospectively enrolled 71 consecutive T2DM patients (mean age: 68 ± 9, male: 79%) with 153 coronary artery lesions. Patients were divided into 2 groups according to eGFR level: the normal eGFR group (≥60 mL/min/1.73m2, n = 40) and the low eGFR group (<60 mL/min/1.73m2, n = 31). All patients underwent continuous glucose monitoring for 120 hours and the mean amplitude of glycemic excursions (MAGE) were calculated. Serum TNF-α was also measured. In addition, iMap-coronary intravascular ultrasound (IVUS) and gray-scale...