S1291 Gastrointestinal Manifestations of Coronavirus Disease-2019 (COVID-19): Single Center Experience

INTRODUCTION: Considering the rapid spread of SARS-CoV2, the clinical implications of gastrointestinal manifestations of COVID-19 in the U S population requires analysis METHODS: We retrospectively reviewed all adult patients with COVID-19 admitted to our facility between March 13th - May 1st, 2020 Patients were divided into two groups based on the presence of GI symptoms at presentation All patients with at least one of the following symptoms, such as anorexia, nausea, vomiting, diarrhea, or abdominal pain at presentation, were considered positive for GI symptoms Kruskal-Wallis and Pearson's chi-square tests were used to compare median of continuous and categorical variables, respectively Multivariate logistic regression analysis was performed to identify predictors of mechanical ventilation, cytokine release syndrome (CRS), and mortality after adjusting for baseline variables RESULTS: A total of 84 patients were included in the analysis Forty-four (52 3%) patients had GI symptoms The most common GI symptom was diarrhea, followed by nausea and vomiting, anorexia, and abdominal pain Patients with GI symptoms were significantly younger (median age: 60 years) as compared to patients without GI symptoms (median age: 68 years, P = 0 01) There were no differences in baseline demographics as displayed in Table 1 The laboratory, and imaging parameters were also significantly different between the two groups (Table 2) Fifty patients (59 5%) required admission to the intensive care unit (ICU) during their hospitalization ICU admissions were similar between both groups Overall hospital course including vasopressor use and duration were not significantly different in both groups and are displayed in Table 3 After adjusting for baseline comorbidities, the presence of GI symptoms was associated a higher risk of development of cytokine release syndrome (adjusted odds ratio (aOR): 4 27 (1 17-15 60, P = 0 03) There was no difference in the need for MV and mortality between both groups on multivariate analysis (OR: 1 53 (0 47-4 94) P = 0 47 and 0 57 (0 08-3 96) P = 0 57, respectively) CONCLUSION: Majority of patients with COVID-19 had at least one GI symptom at presentation Diarrhea was the most common GI symptom followed by nausea/vomiting and loss of appetite The need for mechanical ventilation and mortality was not different among patients with and without GI symptoms in our western study population (Figure Presented)