Морфологические особенности большой подкожной вены у больных варикозной болезнью ассоциированной с дисплазией соединительной ткани

The results of histological study of 47 fragments of the great saphenous vein (GSV) cut out during phlebectomy in the upper third of the hip of 47 patients operated for lower limbs varicose veins disease (LLVVD). Operated patients had various stages of chronic venous insufficiency of lower limbs against a background of connective tissue dysplasia (CTD) of various intensity degrees. To assess the stage of chronic venous insufficiency (CVI) the international classification of lower limbs chronic veins disease was used (CEAP) (1994). Assessment of the degree of connective tissue dysplasia was made based on 82 phenotypic characters using the integral method proposed by T.Y. Smolnova (2009). The studies found that the great saphenous vein of patients with lower limbs varicose veins disease associated with connective tissue dysplasia has specific morphological features expressed by uneven distribution of elastic and collagenous fibers in the vascular wall. Accumulation and uneven distribution of glycosaminoglycans in the vascular wall were reported indicating the initiation of connective tissue damage mechanisms resulting in the development of dystrophic processes in the tissue and in strength reduction of connective tissue carcass.