A combinatorial approach to the identification of cysteine protease substrates and inhibitors by application of a solid-phase fluorescence quenching assay

Phaedria M. St. Hilaire, Sanya Sanderson, Maria A. Juliano, Marianne Willert, Jeremy Mottram, Graham Coombs, Luiz Juliano, and Morten Meldal Department of Chemistry, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Valby, Denmark; Division of Infection and Immunity, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland; and 3 Department of Biophysics, Escola Paulista de Medicina, Rua Tres de Maio 100, 04044-20 Sao Paulo, Brazil.