The Evaluation on the Effectiveness as a Cosmetic Material of Glycosaminoglycans Extracted from Halocynthia roretzi Tunic

This study was designed to examine antioxidant and moisturizing effect of purified GAGS from ascidian tunics as functional cosmetic ingredient. A skin-tonner and essence which contain 1.0% of GAG were manufactured conventionally. These product then were tested for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, collagenase inhibitory activity, collagen-formation stimulator, and fibroblast-proliferation promoter abilities. The DPPH scavenging activity for skin-tonner and essence were 20.5% and 12.4% respectively. Collagenase inhibitory activity of skin-tonner was higher (94.6%) than the essence (80.1%). Skin-tonner and essence with GAGs showed collagen-formation stimulation ability, which were 129.9% and 120.2% respectively. These products also demonstrated significant (p<0.01) fibroblast-proliferation promoter abilities.