selective inhibitors of norepinephrine reuptake in the treatment of hot flashes.

The use of a selective inhibitor of norepinephrine reuptake for the manufacture of a medicament for the treatment of hot flashes and vasomotor symptoms, wherein said selective inhibitor of norepinephrine reuptake is a compound of formula (IH): ( see formula) wherein, X is OH, C1-C4 alkoxy, NH2 or NH (C1-C4); Rx is H or C1-C4 alkyl; Ry is H or C1-C4 alkyl; each Rz group is independently H or C1-C4 alkyl, with the proviso that no more than 3 Rz groups may be C1-C4 alkyl; R1 is C1-C6 alkyl (optionally substituted with 1, 2 or 3 halogen atoms and / or with 1 substituent selected from C1-C4 alkylthio (optionally substituted with 1, 2 or 3 fluorine atoms), C1-C4 alkoxy (optionally substituted with 1, 2 or 3 fluorine atoms), C3-C6 cycloalkoxy, C1-C4 alkylsulfonyl, cyano, -CO-O (C1-C2), -O-CO- (C1-C2) and hydroxy); C2-C6 alkenyl (optionally substituted with 1, 2 or 3 halogen atoms); C3- C6 cycloalkyl (optionally substituted with 1, 2 or 3 halogen atoms and / or with 1 substituent selected from C1-C4 alkoxy and hydroxy) wherein one C-C bond within the cycloalkyl moiety is optionally substituted with one OC, S- C or C = C bond; C4-C7 cycloalkylalkyl (optionally substituted with 1, 2 or 3 halogen atoms and / or with 1 substituent selected from C1-C4 alkoxy and hydroxy) wherein one C-C bond within the cycloalkyl moiety is optionally substituted with one OC, SC or a C = C bond; or CH2Ar2; and Ar1 and Ar2 are each independently a phenyl ring or a heteroaryl ring of 5 or 6 members each of which is optionally substituted with 1, 2 or 3 substituents (depending on the number of substitutable positions available) each independently selected from alkyl C1-C4 alkyl (optionally substituted with 1, 2 or 3 halogen atoms), C1-C4 alkoxy (optionally substituted with 1, 2 or 3 halogen atoms), C1-C4 alkylthio (optionally substituted with 1, 2 or 3 carbon atoms halogen), -CO-O (C1-C4), cyano, -NRR, -CONRR, halo and hydroxy and / or with 1 substituent selected from pyridyl, thiophenyl, phenyl, benzyl and phenoxy each of which is optionally substituted ring with 1, 2 or 3 substituents each independently selected from halogen, C1-C4 alkyl (optionally substituted with 1, 2 or 3 halogen atoms), C1-C4 alkoxy (optionally substituted with 1, 2 or 3 carbon atoms halogen), carboxy, nitro, hydroxy, cyano, - NRR, -CONRR, SO2NRR and SO2R); and each R is independently H or C1-C4 alkyl; or a pharmaceutically acceptable salt thereof.