Progress in diagnosis and treatment of severe Kawasaki disease

Kawasaki disease (KD) is an acute systemic small and medium vasculitis syndrome, which is most commonly found in children under the age of 5 years.The most severe complications of KD are coronary artery lesions (CAL), which will lead to coronary artery dilatation, myocardial infarction and sudden death.In the acute stage, severe clinical manifestations are associated with shock, and all organs could be involved, which is called severe Kawasaki disease (SKD), sometimes requiring treatment in the pediatric intensive care unit (PICU) have been reported.Although the clinical symptoms of children with SKD are severe, most patients can survive without any sequelae as long as they can be diagnosed accurately and treated rapidly.In recent years, scholars at home and abroad have paid more and more attention to SKD.Based on these, we take SKD as the research object, try to explain the progress of clinical diagnosis and treatment, which is beneficial to pediatric clinicians to accurately judge and treat related diseases. Key words: Kawasaki disease; Severe Kawasaki disease; Coronary artery lesions; Kawasaki disease shock syndrome